Patios de Cafayate was constructed amid the intellectual and philosophical movement that dominated Europe in the 18th century.

Originally built and named La Rosa in 1740, Patios de Cafayete was utilized as a vast estate that resided next to a cattle ranch. It was not utilized as a hotel until 1998, when La Rosa reopened with just five rooms and finite resources. It underwent a major transformation when a group of architects worked to restore portions of the estate that had been left dormant and desolate for many years. Their expert craftsmanship allowed for the construction of 32 additional rooms for La Rosa, while still maintaining the prized architectural characteristics that were so well-loved: Spanish Colonial-style architecture, walls crafted from adobe, and majestic doorway entrances. Just one year later, the hotel was renamed Patios de Cafayete, which allowed its visitors to delight in historic accommodations restored from centuries ago.

The hotel's rebirth never deserted its initial elements of history, as its story lives on within its walls and in its spacious rooms. The original chapel that resided within the estate still remains today, with intricate details crafted in the city of Peruvian city of Cusco. Original artworks reside on the walls dreamed up by local artists, and handwoven upholstery graces its interior. With its original identity never amiss, the hotel has grown and changed, but has never allowed its visitors to forget its beautiful story of creation and everlasting existence.